Goserline versus danazol in the treatment of endometriosis

The objective of this study was to achieve symptoms relief of endometriosis with a drug having better efficacy and least side effects. Experimental. Lady Willingdon Hospital, Lahore from March, 2003 to Feb. 2005. The trial was conducted on two groups; one group [n = 20] received goserline and other group [n=20] received danazol for 6 months. Patients were followed for relief of symptoms including dysmenorrhoea, dyspareunia, lower abdominal pain and menstrual irregularity and appearance of side effects. The results depicted that in Danazol group 50% pain relief was found in 5 patients [25%] while in goserline group in 4 patients [20%]. 75% pain relief was seen in 7 patients [35%] in danazol group and 8 patients [40%] in goserline group. 100% of improvement in pain found in equal number of patient that is 8[40%] in both groups. Both drugs were effective in pain relief [P >0.05], Goserline had less side effects as compared to Danazol [P<0.05]. Goserline and Danazol are equally effective in symptomatic relief of endometriosis while side effects favoured use of GnRH agonist

Vesico vaginal fistula: prevention is possible

A prospective study was conducted at Lady Willingdon hospital Lahore from Jan,2002 to Dec, 2004. During the mentioned period 22 patients were admitted with the diagnosis of urinary tract fistula. Among these most of the patients [i.e, 45%] were young belonging to age group 20-30 years. According to the causes 72% were due to obstetrical causes, 23% due to surgical causes and 5% were due to malignant. Regarding to the location of the fistula 14% were juxtauretheral,28% low vaginal, 35% mid vaginal,09% high vaginal and 14% were vault fistulae.Out of 22 patients first surgical repair failure occurred in four patients

Primary postparum haemorrhage; effective treatment modalities

Post partum hemorrhage is one of the leading causes of maternal mortality. A prospective study was conducted at Unit III Lady Willingdon Hospital Lahore, from July 2002 to June 2004. During the mentioned period 196 patients with primary PPH were included in the study. Evaluation was done in detail for the risk and causative factors, effective treatment modalities and morbidity and mortality associated with PPH. According to results it was more common among unhooked and multiparous patients. The commonest cause was uterine atony in 54% cases. Most of the patients responded to medical or surgical treatment with average hospital stay of 7 days. Anemia was found in 78% of cases, while other complications included puerperal pyrexia, UTI and wound infection

Vaginal prostaglandin E2 pessary versus gel in induction of labour at term

To compare the prostaglandin E2 Vaginal pessary and gel with respect to cervical ripening, labour out come, side effects and cost effectiveness in induction of labour at term. Experimental study. Lady Willingdon Hospital, Lahore February to July, 2005. The trial was conducted on two group of patient for labour induction such that one group [n=30] received PGE2 vaginal pessary 6 hourly to maximum of 3 doses. Other group [n=30] received PGE2 gel at 6 hourly interval upto 2 doses. Labour induction, number of doses applied, need of augmentation, side effects, induction to delivery interval, mode of delivery, neonatal outcome and cost effectiveness were the main outcome measures. Our results depicted that PGE2 gel produced favourable bishop score more rapidly and initiating uterine contraction simultaneously than PGE2 pessary. Few patients required oxytocin augmentation in gel group [P<0.05]. There was no statistically significant d ifference in number of patients delivering vaginally with in 24 hours, the neonatal outcome and cost effectiveness in two groups [P>0.05]. However, more side effects such as uterine contractions, abnormalities, and fetal distress observed in gel group [P<0.05]. The PGE2 pessary was safe and easily applied, but PGE2 intracervical gel was more effective as it achieved greater changes in mean bishop score. However, more side effects encountered with gel catego

prevalence and age distribution of ovarian cysts

A prospective study conducted at Lady Willingdon Hospital LHR over two years for prevalence and age distribution of ovarian cyst. According to study 85% ovarian cyst were benign, 13% cyst were malignant while 2% were borderline malignant. The commonest histopathological type was serous cystadenoma. Only age was not the determining factor for the type of the ovarian cyst